Fluoride is the occasion of a large application areas of significant progress in oral medicine, it caries, desensitization and other aspects of the application is very wide. The role of fluoride include: ① inhibiting the growth of cariogenic bacteria; ② reduce plaque formation in acid; ③ reduce the solubility of enamel; ④ promote the remineralization of enamel decalcification. Fluoride concentration and control in a certain dose of the anti-caries effect. If the dose or concentration is too large, can cause fluorosis (fluoride poisoning). Protoplasmic poison fluoride to cells when using excessive doses, or inadvertently, when the concentration is too high, the body will cause serious consequences. 6 ~ 8mg/kg (weight) of fluoride can cause death. Been reported, one oral 100mg, which lead to acute fluoride poisoning. Children with acute fluoride poisoning dose 2mg/kg body weight, infants with a capacity Dental Artcles of 1g of sodium fluoride, can endanger lives. Long-term intake of excessive fluoride can cause the body from chronic fluoride poisoning.
Acute fluoride poisoning is extremely rare, can cause acute gastrointestinal irritation; and serum calcium fluoride can not be combined to form of calcium fluoride, the result is caused by muscle spasms, collapse and breathing difficulties; chronic poisoning can affect the teeth, bone or other organization. Fluoride content of drinking water plus 2 ~ 4mg / L may cause dental fluorosis; 4 ~ 14mg / L can cause skeletal fluorosis (osteofluorosis), rickets, anemia and joint disease and so on. All this shows that increases in the amount of fluoride in drinking water or fluoride to dental caries through other means, if applied correctly, will not cause much side effects. One approach is the joint use of fluoride, fluoride can reduce the use of local, but also improve the anti-caries effect, means is worthwhile to promote dental caries.
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